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Chl1tm1Mtg
Targeted Allele Detail
Nomenclature
Symbol: Chl1tm1Mtg
Name: cell adhesion molecule L1-like; targeted mutation 1, Dirk Montag
MGI ID: MGI:2429688
Synonyms: Chl1-, CHL1-deficient
Gene: Chl1  Location: Chr6:103510586-103750211 bp, + strand  Genetic Position: Chr6, 47.97 cM, cytoband E1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79902
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacement of exon 1 (and 4 kb of intron 1) with a PGK-neo cassette via homologous recombination, thus deleting the ribosomal binding site, translation initiation codon, and signal sequence. Absence of gene expression in homozygous mutant animals was verified by Western blot analysis of brain protein extracts. (J:79902)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 15 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chl1 Mutation:  22 strains or lines available
References
Original:  J:79902 Montag-Sallaz M, et al., Misguided axonal projections, neural cell adhesion molecule 180 mRNA upregulation, and altered behavior in mice deficient for the close homolog of L1. Mol Cell Biol. 2002 Nov;22(22):7967-81
All:  19 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory