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Targeted Allele Detail
Symbol: Chl1tm1Mtg
Name: cell adhesion molecule L1-like; targeted mutation 1, Dirk Montag
MGI ID: MGI:2429688
Synonyms: Chl1-, CHL1-deficient
Gene: Chl1  Location: Chr6:103510584-103733038 bp, + strand  Genetic Position: Chr6, 47.97 cM, cytoband E1
Germline Transmission:  Earliest citation of germline transmission: J:79902
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exon 1 (and 4 kb of intron 1) with a PGK-neo cassette via homologous recombination, thus deleting the ribosomal binding site, translation initiation codon, and signal sequence. Absence of gene expression in homozygous mutant animals was verified by Western blot analysis of brain protein extracts. (J:79902)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 15 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chl1 Mutation:  30 strains or lines available
Original:  J:79902 Montag-Sallaz M, et al., Misguided axonal projections, neural cell adhesion molecule 180 mRNA upregulation, and altered behavior in mice deficient for the close homolog of L1. Mol Cell Biol. 2002 Nov;22(22):7967-81
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory