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Targeted Allele Detail
Symbol: Cabin1tm1.1Che
Name: calcineurin binding protein 1; targeted mutation 1.1, Jianzhu Chen
MGI ID: MGI:2429675
Synonyms: Cabin1DeltaC
Gene: Cabin1  Location: Chr10:75646110-75764357 bp, - strand  Genetic Position: Chr10, 38.56 cM
Germline Transmission:  Earliest citation of germline transmission: J:72760
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThe floxed neomycin selection cassette that had replaced the last two exons of the endogenous gene was excised from Cabin1tm1Che via in vivo cre mediated recombination. The deleted region encoded the carboxy terminal which includes the calcineurin, calmodulin, and MEF2 binding domains. Northern blot analysis of homozygous mutant mice identified a transcript of the anticipated size in brain and thymus tissue. While RT-PCR and subsequent sequence analysis showed that translation of this transcript could result in a truncated protein that contained 4 new amino acid residues in place of the endogenous carboxy terminal, the lack of an amino terminal antibody prevented direct confirmation of such a peptide. (J:72760)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cabin1 Mutation:  65 strains or lines available
Original:  J:72760 Esau C, et al., Deletion of Calcineurin and Myocyte Enhancer Factor 2 (MEF2) Binding Domain of Cabin1 Results in Enhanced Cytokine Gene Expression in T Cells. J Exp Med. 2001 Nov 19;194(10):1449-59
All:  1 reference(s)

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MGI 6.06
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