Cd200^tm1Jods
Targeted Allele Detail

Nomenclature

Symbol:	Cd200^tm1Jods
Name:	CD200 antigen; targeted mutation 1, Jonathon D Sedgwick
MGI ID:	MGI:2429651
Synonyms:	CD200^-
Gene:	Cd200  Location: Chr16:45382135-45409053 bp, - strand  Genetic Position: Chr16, 29.53 cM, cytoband A1

Mutation origin

Germline Transmission:	Earliest citation of germline transmission: J:65982
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Mutation description

Allele Type:		Targeted (Null/knockout)
Mutations:		Insertion, Intragenic deletion
		Mutation details: A portion of exon 3 was replaced by a neomycin selection cassette. Protein expression was examined by immunohistochemical and flow cytometric analyses and determined to be absent in the CNS, B cells, follicular dendritic cells, and splenic endothelium of homozygous mutant mice. (J:65982)

Disease models

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd200 Mutation:	2 strains or lines available

References

Original:	J:65982 Hoek RM, et al., Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science. 2000 Dec 1;290(5497):1768-71
All:	14 reference(s)