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Cd200tm1Jods
Targeted Allele Detail
Nomenclature
Symbol: Cd200tm1Jods
Name: CD200 antigen; targeted mutation 1, Jonathon D Sedgwick
MGI ID: MGI:2429651
Synonyms: CD200-
Gene: Cd200  Location: Chr16:45382135-45409053 bp, - strand  Genetic Position: Chr16, 29.53 cM, cytoband A1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65982
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA portion of exon 3 was replaced by a neomycin selection cassette. Protein expression was examined by immunohistochemical and flow cytometric analyses and determined to be absent in the CNS, B cells, follicular dendritic cells, and splenic endothelium of homozygous mutant mice. (J:65982)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd200 Mutation:  12 strains or lines available
References
Original:  J:65982 Hoek RM, et al., Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science. 2000 Dec 1;290(5497):1768-71
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/31/2018
MGI 6.12
The Jackson Laboratory