Cd200^tm1Jods
Targeted Allele Detail

Nomenclature

• Symbol: Cd200^tm1Jods
• Name: CD200 antigen; targeted mutation 1, Jonathon D Sedgwick
• MGI ID: MGI:2429651
• Synonyms: CD200^-
• Gene: Cd200 Location: Chr16:45382135-45409053 bp, - strand Genetic Position: Chr16, 29.53 cM, cytoband A1

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:65982
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A portion of exon 3 was replaced by a neomycin selection cassette. Protein expression was examined by immunohistochemical and flow cytometric analyses and determined to be absent in the CNS, B cells, follicular dendritic cells, and splenic endothelium of homozygous mutant mice. (J:65982)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd200 Mutation: 12 strains or lines available

References

• Original: J:65982 Hoek RM, et al., Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science. 2000 Dec 1;290(5497):1768-71
• All: 18 reference(s)