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Tln1tm3Crit
Targeted Allele Detail
Nomenclature
Symbol: Tln1tm3Crit
Name: talin 1; targeted mutation 3, David R Critchley
MGI ID: MGI:2429596
Synonyms: Tln1neo, Tlnneo
Gene: Tln1  Location: Chr4:43531513-43562583 bp, - strand  Genetic Position: Chr4, 23.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65873
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe endogenous locus was disrupted by the insertion of a neomycin selection cassette. Sequences corresponding to codons 37 through 66 were replaced. (J:65873)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tln1 Mutation:  108 strains or lines available
References
Original:  J:65873 Monkley SJ, et al., Disruption of the talin gene arrests mouse development at the gastrulation stage. Dev Dyn. 2000 Dec;219(4):560-74
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory