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Irs2tm1Tka
Targeted Allele Detail
Nomenclature
Symbol: Irs2tm1Tka
Name: insulin receptor substrate 2; targeted mutation 1, Takashi Kadowaki
MGI ID: MGI:2429574
Synonyms: Irs2-, IRS-2-
Gene: Irs2  Location: Chr8:10986961-11008430 bp, - strand  Genetic Position: Chr8, 5.35 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:65485
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irs2 Mutation:  1 strain or line available
References
Original:  J:65485 Kubota N, et al., Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. Diabetes. 2000 Nov;49(11):1880-9
All:  20 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory