Dice1^C57BL/6
QTL Variant Detail

Summary

• QTL variant: Dice1^C57BL/6
• Name: determination of interleukin 4 commitment 1; C57BL/6
• MGI ID: MGI:2429565
• QTL: Dice1 Location: Chr16:11434246-11434358 bp Genetic Position: Chr16, cM position of peak correlated region/allele: 6.54 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C57BL/6

Variant description

• Allele Type: QTL
• Inheritance: Not Specified

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:51707

63 C57BL/6 x (C57BL/6 x BALB/c)F1 backcross animals were analyzed via genome scan to identify QTLs associated with IL-4 levels. Parental inbred strain BALB/c exhibits 40 times more IL-4 than parental strain C57BL/6. Linkage was found on mouse chromosome 16 with a QTL range from 4.3 cM - 8.6 cM and LOD = 3.8 at D16Mit81. The locus was named Dice1 (determination of IL-4 commitment 1). A suggestive QTL mapped to mouse chromosome 7 near D7Mit103 at approximately 63.5 cM. This locus was named Dice2.

References

• Original: J:51707 Bix M, et al., Genetic regulation of commitment to interleukin 4 production by a CD4(+) T cell-intrinsic mechanism. J Exp Med. 1998 Dec 21;188(12):2289-99
• All: 1 reference(s)