Tg(Wap-Mmp3)5Sym
Transgene Detail

Summary

• Symbol: Tg(Wap-Mmp3)5Sym
• Name: transgene insertion 5, Carolyn J Sympson
• MGI ID: MGI:2429539
• Synonyms: M2-5, WAP-MMP-3
• Transgene: Tg(Wap-Mmp3)5Sym Location: unknown
• Alliance: Tg(Wap-Mmp3)5Sym page

Transgene origin

• Strain of Origin: CD-1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Wap-Mmp3)5Sym expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Mmp3 (171045)

  Mmp3	(MGI:97010)

• Mutation details: Modified rat matrix metalloproteinase 3 (Mmp3) sequence was adjoined to a 2.4 kb murine Wap promoter fragment. The Mmp3 sequence contained a valine to glycine substitution mutation at codon 92 (see Erratum for J:18003), thereby conferring autoactivation. Immunocytochemical analysis identified abundant transgenic protein in mammary tissues in pregnant and lactating mice. (J:18003)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Wap-Mmp3)5Sym

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:18003 Sympson CJ, et al., Targeted expression of stromelysin-1 in mammary gland provides evidence for a role of proteinases in branching morphogenesis and the requirement for an intact basement membrane for tissue-specific gene expression. J Cell Biol. 1994 May;125(3):681-93
• All: 4 reference(s)