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QTL Variant Detail
QTL variant: Rapop5C57BL/6J
Name: radiation-induced apoptosis 5; C57BL/6J
MGI ID: MGI:2429537
QTL: Rapop5  Location: Chr15:9272936-79590561 bp  Genetic Position: Chr15, cM position of peak correlated region/allele: 19.26 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Strain of Specimen:  C57BL/6J
Allele Type:    QTL
Inheritance:    Not Specified

Mapping and Phenotype information for this QTL, its variants and associated markers


A genome wide scan was performed using female animals from a (C57BL/6J x C3Hf/Kam)F2 cross to uncover loci involved in radiation-induced apoptosis of jejunal crypt cells. 159 markers at an average spacing spacing of 10 cM were used in the genome scan. Rapop5, a QTL involved in radiation-induced apoptosis of jejunal cells, mapped to mouse Chromosome 15 with a peak LOD score of 3.35 between markers D15Mit100 and D15Mit17. C57BL/6J animals show higher levels of cellular apoptosis compared to C3Hf/Kam animals, either with or without exposure to low-dose radiation. In addition, seven different strains carrying recombinations in Chromosome 15 were constructed by a series of (C57BL/6J x C3Hf/Kam) x C3Hf/Kam backcrosses to confirm and localize Rapop5. Rapop5 wasconfirmed and localized to a region on Chromosome 15 between markers D15Mit175 and D15Mit71 . Four QTLs influencing radiation-induced apoptosis in thymus cells, Rapop1 (chromosome 16), Rapop2 (Chromosome 9), Rapop3 (Chromosome 3), and Rapop4 (Chromosome 11), were previously mapped using the same cross.

Original:  J:68174 Weil MM, et al., A chromosome 15 quantitative trait locus controls levels of radiation-induced jejunal crypt cell apoptosis in mice. Genomics. 2001 Feb 15;72(1):73-7
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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