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Adgrv1frings
Spontaneous Allele Detail
Nomenclature
Symbol: Adgrv1frings
Name: adhesion G protein-coupled receptor V1; frings
MGI ID: MGI:2389570
Synonyms: frings, Mass1frings
Gene: Adgrv1  Location: Chr13:81243187-81781273 bp, - strand  Genetic Position: Chr13, 42.18 cM
Mutation
origin
Strain of Origin:  various
Mutation
description
Allele Type:    Spontaneous
Mutation:    Intragenic deletion
 
Mutation detailsThe phenotype of the Frings mouse has been attributed to a single nucleotide deletion (guanine 7009) that results in a nonsense mutation in exon 27 (codon 2072). The stop codon putatively precludes translation of a multicopper oxidase (MCOI) consensus site in all three splice variants. The allele was originally described in RB/1 strain, but subsequently the same mutation was found in BUB/BnJ strain but not in 11 other strains of Swiss albino mice. (J:71344)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Adgrv1 Mutation:  188 strains or lines available
References
Original:  J:25341 Frings H, et al., The production of stocks of albino mice with predictable susceptibilities to audiogenic seizures. Behaviour. 1953;5:305-19
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory