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Ak1tm1Bew
Targeted Allele Detail
Nomenclature
Symbol: Ak1tm1Bew
Name: adenylate kinase 1; targeted mutation 1, Be Wieringa
MGI ID: MGI:2389509
Synonyms: AK1-
Gene: Ak1  Location: Chr2:32621758-32635058 bp, + strand  Genetic Position: Chr2, 22.09 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66101
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 3 through 5, encoding the ATP binding site, were replaced with a hygromycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of skeletal muscle, heart, and brain tissue obtained from homozygous mutant mice. Zymogram analysis of various tissues confirmed the absence of functional protein. (J:66101)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ak1 Mutation:  25 strains or lines available
References
Original:  J:66101 Janssen E, et al., Adenylate kinase 1 gene deletion disrupts muscle energetic economy despite metabolic rearrangement. EMBO J. 2000 Dec 1;19(23):6371-81
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory