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Sncatm1Nbm
Targeted Allele Detail
Nomenclature
Symbol: Sncatm1Nbm
Name: synuclein, alpha; targeted mutation 1, Robert L Nussbaum
MGI ID: MGI:2389489
Synonyms: Scna-, Snca-
Gene: Snca  Location: Chr6:60731575-60829855 bp, - strand  Genetic Position: Chr6, 29.15 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79784
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4 and 5 were replaced with a neomycin selection cassette inserted by homologous recombination. While the separation of Western blot results by 2D-PAGE showed various isoforms in total brain extract obtained from wild-type mice, protein was undetected in samples obtained from homozygous mutant mice. (J:79784)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Snca Mutation:  17 strains or lines available
References
Original:  J:79784 Cabin DE, et al., Synaptic vesicle depletion correlates with attenuated synaptic responses to prolonged repetitive stimulation in mice lacking alpha-synuclein. J Neurosci. 2002 Oct 15;22(20):8797-807
All:  19 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory