Tnfrsf13c^Bcmd1
Spontaneous Allele Detail

Summary

• Symbol: Tnfrsf13c^Bcmd1
• Name: tumor necrosis factor receptor superfamily, member 13c; B-cell maturation defect 1
• MGI ID: MGI:2389403
• Synonyms: Baffr^m, Bcmd1^A/WySnJ, Tnfrsf13c^{Bcmd1-A/WySnJ}
• Gene: Tnfrsf13c Location: Chr15:82105944-82108570 bp, - strand Genetic Position: Chr15, 38.56 cM
• Alliance: Tnfrsf13c^Bcmd1 page

Mutation origin

• Strain of Origin: A/WySnJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Transposon insertion
• Mutation details: In the A/WySnJ strain of mice, an intracisternal type A particle retrotransposon insertion occurred in exon 3, resulting in the replacememt of the final 8 amino acids of the encoded protein with 21 amino acids from the inserted element. This mutation is not present in A/J. FACS analysis indicated that an aberrant fusion protein was expressed from this allele that appeared on the cell surface; however, the protein appeared to be nonfuctional. (J:71680, J:82993)

Expression

In Mice Carrying this Mutation:	35 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfrsf13c Mutation: 14 strains or lines available

References

• Original: J:65139 Hoag KA, et al., A quantitative-trait locus controlling peripheral B-cell deficiency maps to mouse Chromosome 15. Immunogenetics. 2000 Sep;51(11):924-9
• All: 17 reference(s)