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Spontaneous Allele Detail
Symbol: Tnfrsf13cBcmd1
Name: tumor necrosis factor receptor superfamily, member 13c; B-cell maturation defect 1
MGI ID: MGI:2389403
Synonyms: Baffrm, Bcmd1A/WySnJ, Tnfrsf13cBcmd1-A/WySnJ
Gene: Tnfrsf13c  Location: Chr15:82105944-82108570 bp, - strand  Genetic Position: Chr15, 38.56 cM
Strain of Origin:  A/WySnJ
Allele Type:    Spontaneous
Mutation:    Transposon insertion
Mutation detailsIn the A/WySnJ strain of mice, an intracisternal type A particle retrotransposon insertion occurred in exon 3, resulting in the replacememt of the final 8 amino acids of the encoded protein with 21 amino acids from the inserted element. This mutation is not present in A/J. FACS analysis indicated that an aberrant fusion protein was expressed from this allele that appeared on the cell surface; however, the protein appeared to be nonfuctional. (J:71680, J:82993)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 35 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tnfrsf13c Mutation:  10 strains or lines available
Original:  J:65139 Hoag KA, et al., A quantitative-trait locus controlling peripheral B-cell deficiency maps to mouse Chromosome 15. Immunogenetics. 2000 Sep;51(11):924-9
All:  17 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory