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Bace1tm1Pcw
Targeted Allele Detail
Nomenclature
Symbol: Bace1tm1Pcw
Name: beta-site APP cleaving enzyme 1; targeted mutation 1, Philip C Wong
MGI ID: MGI:2389228
Synonyms: Bace1-, BACE1-
Gene: Bace1  Location: Chr9:45838580-45864399 bp, + strand  Genetic Position: Chr9, 25.22 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79847
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Normal protein was undetected by Western blot analysis of homozygous mutant embryos. (J:79847)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bace1 Mutation:  3 strains or lines available
References
Original:  J:79847 Cai H, et al., BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat Neurosci. 2001 Mar;4(3):233-4
All:  34 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory