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Blnktm1Achn
Targeted Allele Detail
Nomenclature
Symbol: Blnktm1Achn
Name: B cell linker; targeted mutation 1, Andrew C Chan
MGI ID: MGI:2389137
Synonyms: BLNK-
Gene: Blnk  Location: Chr19:40928927-40994535 bp, - strand  Genetic Position: Chr19, 34.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:58805
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsExon 1 was disrupted by homologous recombination of a construct containing GFP, a floxed neo gene, and a mutated start codon (ATC). While the GFP coding region was linked to its own Kozak sequence and start codon, fluorescence was undetected in splenocytes and bone marrow cells derived from heterozygous mutant mice. Immunoblot analysis on homozygote bone marrow cells failed to detect Blnk protein. (J:58805)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Blnk Mutation:  51 strains or lines available
References
Original:  J:58805 Pappu R, et al., Requirement for B cell linker protein (BLNK) in B cell development. Science. 1999 Dec 3;286(5446):1949-54
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/12/2015
MGI 5.21
The Jackson Laboratory