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Il12atm1Cab
Targeted Allele Detail
Nomenclature
Symbol: Il12atm1Cab
Name: interleukin 12a; targeted mutation 1, Christine A Biron
MGI ID: MGI:2388729
Synonyms: IL-12P35-, p35-
Gene: Il12a  Location: Chr3:68690644-68698547 bp, + strand  Genetic Position: Chr3, 31.92 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:54482
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 1 through 4 were replaced with a neomycin selection cassette. Interleukin 12 heterodimers were undetected after LPS stimulation or MCMV infection. (J:54482)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il12a Mutation:  22 strains or lines available
References
Original:  J:54482 Cousens LP, et al., Two roads diverged: interferon alpha/beta- and interleukin 12-mediated pathways in promoting T cell interferon gamma responses during viral infection. J Exp Med. 1999 Apr 19;189(8):1315-28
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory