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Targeted Allele Detail
Symbol: Mycntm1Psk
Name: v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived; targeted mutation 1, Paul S Knoepfler
MGI ID: MGI:2388717
Synonyms: Mycnloxp, Mycntm1Rne, NmycFl, N-mycFL
Gene: Mycn  Location: Chr12:12986094-12991837 bp, - strand  Genetic Position: Chr12, 6.14 cM, cytoband A3-B
Germline Transmission:  Earliest citation of germline transmission: J:79489
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsSequence encompassing exons 2 and 3 was flanked by a single loxP site upstream and a floxed neo cassette downstream. RT-PCR analysis revealed a 25% to 30% reduction in the amount of transcript in homozygous mutant mice. (J:79489)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 103974 assay results
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 2 lines available
Carrying any Mycn Mutation:  20 strains or lines available
Original:  J:79489 Knoepfler PS, et al., N-myc is essential during neurogenesis for the rapid expansion of progenitor cell populations and the inhibition of neuronal differentiation. Genes Dev. 2002 Oct 15;16(20):2699-712
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.17
The Jackson Laboratory