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Trp53tm1Mok
Targeted Allele Detail
Nomenclature
Symbol: Trp53tm1Mok
Name: transformation related protein 53; targeted mutation 1, Motoya Katsuki
MGI ID: MGI:2388704
Gene: Trp53  Location: Chr11:69580359-69591873 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Mutation
origin
Mouse Generated:  Earliest citation of chimera generation: J:79629
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacment of exons 2-10 with a neo-TK cassette via homologous recombination. Germline founder animals were established but did not transmit the mutant allele to offspring, indicating a 100% segregation distortion. Authors hypothesize the HSV-TK gene is responsible for the lack of allele transmission. (J:79629)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  133 strains or lines available
References
Original:  J:79629 Gondo Y, et al., Gene replacement of the p53 gene with the lacZ gene in mouse embryonic stem cells and mice by using two steps of homologous recombination. Biochem Biophys Res Commun. 1994 Jul 29;202(2):830-7
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/17/2015
MGI 5.21
The Jackson Laboratory