Oprm1tm1Loh
Targeted Allele Detail
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Symbol: |
Oprm1tm1Loh |
Name: |
opioid receptor, mu 1; targeted mutation 1, Horace H Loh |
MGI ID: |
MGI:2388673 |
Synonyms: |
MOP-KO, MORKO |
Gene: |
Oprm1 Location: Chr10:6708593-6988209 bp, + strand Genetic Position: Chr10, 1.85 cM, cytoband A2
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Alliance: |
Oprm1tm1Loh page
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Germline Transmission: |
Earliest citation of germline transmission:
J:47187
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Parent Cell Line: |
HM-1 (ES Cell)
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Strain of Origin: |
129P2/OlaHsd-Hprt1b-m3
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: Exons 2 and 3 where replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded six of the seven transmembrane domains. Ligand binding assays demonstrated the absence of a functional protein product. Phenotypic observations further indicated the ablation of both receptor subtypes.
(J:47187)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Oprm1 Mutation: |
53 strains or lines available
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Original: |
J:47187 Loh HH, et al., mu Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality. Brain Res Mol Brain Res. 1998 Mar 1;54(2):321-6 |
All: |
39 reference(s) |
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