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Targeted Allele Detail
Symbol: Oprm1tm1Loh
Name: opioid receptor, mu 1; targeted mutation 1, Horace H Loh
MGI ID: MGI:2388673
Synonyms: MOP-KO, MORKO
Gene: Oprm1  Location: Chr10:6758593-7038209 bp, + strand  Genetic Position: Chr10, 1.85 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:47187
Parent Cell Line:  HM-1 (ES Cell)
Strain of Origin:  129P2/OlaHsd-Hprtb-m3
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 2 and 3 where replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded six of the seven transmembrane domains. Ligand binding assays demonstrated the absence of a functional protein product. Phenotypic observations further indicated the ablation of both receptor subtypes. (J:47187)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Oprm1 Mutation:  35 strains or lines available
Original:  J:47187 Loh HH, et al., mu Opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality. Brain Res Mol Brain Res. 1998 Mar 1;54(2):321-6
All:  37 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory