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Fzd3tm1Nat
Targeted Allele Detail
Nomenclature
Symbol: Fzd3tm1Nat
Name: frizzled class receptor 3; targeted mutation 1, Jeremy Nathans
MGI ID: MGI:2388632
Synonyms: fz3(-)
Gene: Fzd3  Location: Chr14:65192449-65262463 bp, - strand  Genetic Position: Chr14, 34.09 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79213
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe coding regions of the exons 1 and 2 were replaced with a cassette containing lacZ and neo genes. The deleted region encoded the amino terminal signal sequence and a conserved extracellular domain that has been previously been shown to be involved wiht Wnt binding. The expression pattern of beta-galactosidase replicated that of the endogenous gene. (J:79213)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 9 assay results
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fzd3 Mutation:  7 strains or lines available
References
Original:  J:79213 Wang Y, et al., Frizzled-3 is required for the development of major fiber tracts in the rostral CNS. J Neurosci. 2002 Oct 1;22(19):8563-73
All:  16 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory