Gbx2^tm1Alj
Targeted Allele Detail

Summary

• Symbol: Gbx2^tm1Alj
• Name: gastrulation brain homeobox 2; targeted mutation 1, Alexandra L Joyner
• MGI ID: MGI:2388609
• Synonyms: Gbx2^flox-neo
• Gene: Gbx2 Location: Chr1:89855684-89858898 bp, - strand Genetic Position: Chr1, 45.06 cM, cytoband C5-E1
• Alliance: Gbx2^tm1Alj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79431
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted downstream of an frt flanked neo cassette in intron 1 and another loxP site was inserted into the 3' untranslated region of the endogenous locus. Mice carrying this allele were used to generate Gbx2^tm1.1Alj. (J:79431)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gbx2 Mutation: 27 strains or lines available

References

• Original: J:79431 Li JY, et al., Changing requirements for Gbx2 in development of the cerebellum and maintenance of the mid/hindbrain organizer. Neuron. 2002 Sep 26;36(1):31-43
• All: 1 reference(s)