Tg(Hoxb7-RET-C634K)2Vpa
Transgene Detail

Summary

• Symbol: Tg(Hoxb7-RET-C634K)2Vpa
• Name: transgene insertion 2, Vassilis Pachnis
• MGI ID: MGI:2388561
• Synonyms: Hoxb7-Ret51-MEN2B
• Transgene: Tg(Hoxb7-RET-C634K)2Vpa Location: unknown
• Alliance: Tg(Hoxb7-RET-C634K)2Vpa page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Hoxb7-RET-C634K)2Vpa expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  RET (5979)

  Ret	(MGI:97902)

  Transgene codes for a protein with a cysteine to lysine mutation.

• Mutation details: The transgene consists of a human RET cDNA encoding the RET51 isoform with a cysteine to lysine substitution at position 634 (C634K) fused to mouse Hoxb7 promoter sequences (-1316 to +81). Mouse Hoxb7 promoter was used to drive expression of the transgene throughout the uretic bud branches. The C634K mutation is associated with the human disease MEN2A syndrome. (J:71588)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

Trangenic founder mice were sacrificed at day E18.5 for analysis.

References

• Original: J:71588 de Graaff E, et al., Differential activities of the RET tyrosine kinase receptor isoforms during mammalian embryogenesis. Genes Dev. 2001 Sep 15;15(18):2433-44
• All: 1 reference(s)