About   Help   FAQ
Abcc8tm1.1Mgn
Targeted Allele Detail
Nomenclature
Symbol: Abcc8tm1.1Mgn
Name: ATP-binding cassette, sub-family C (CFTR/MRP), member 8; targeted mutation 1.1, Mark A Magnuson
MGI ID: MGI:2388392
Synonyms: SUR1-, Sur1neo
Gene: Abcc8  Location: Chr7:46104523-46180033 bp, - strand  Genetic Position: Chr7, 29.66 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:79352
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe floxed region containing the promoter and exon 1 was excised via cre mediated recombination of Abcctm1Mgn. The neo cassette in intron 1 remained. (J:79352)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Abcc8 Mutation:  38 strains or lines available
References
Original:  J:79352 Shiota C, et al., Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. J Biol Chem. 2002 Oct 4;277(40):37176-83
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/12/2018
MGI 6.12
The Jackson Laboratory