Abcc8^tm1Mgn
Targeted Allele Detail

Summary

• Symbol: Abcc8^tm1Mgn
• Name: ATP-binding cassette, sub-family C member 8; targeted mutation 1, Mark A Magnuson
• MGI ID: MGI:2388391
• Synonyms: Sur1^lox+neo
• Gene: Abcc8 Location: Chr7:45753952-45829441 bp, - strand Genetic Position: Chr7, 29.66 cM
• Alliance: Abcc8^tm1Mgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79352
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The promoter region and exon 1 were flanked by single loxP sites by homologous recombination of a construct which also contained a neo cassette in intron 1, downstream of the 3' loxP site. Mice carrying this allele were used to generate Abcc8^tm1.1Mgn. (J:79352)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abcc8 Mutation: 77 strains or lines available

References

• Original: J:79352 Shiota C, et al., Sulfonylurea receptor type 1 knock-out mice have intact feeding-stimulated insulin secretion despite marked impairment in their response to glucose. J Biol Chem. 2002 Oct 4;277(40):37176-83
• All: 1 reference(s)