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Klk8tm1Lth
Targeted Allele Detail
Nomenclature
Symbol: Klk8tm1Lth
Name: kallikrein related-peptidase 8; targeted mutation 1, Richard Lathe
MGI ID: MGI:2388384
Gene: Klk8  Location: Chr7:43797577-43803826 bp, + strand  Genetic Position: Chr7, 28.26 cM, cytoband B4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71533
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe gene was disrupted by replacment of the region of exon 3 encoding the aspartic acid region of the catalytic site with a lacZ-neo cassette. The targeting construct introduces stop codons in all 3 reading frames. Northern blot analysis of brain RNA verified the absence of gene expression in homozygous mutant animals. X-gal staining of mutant brains did not detect any lacZ expression. (J:71533)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Klk8 Mutation:  14 strains or lines available
References
Original:  J:71533 Davies B, et al., Loss of hippocampal serine protease BSP1/neuropsin predisposes to global seizure activity. J Neurosci. 2001 Sep 15;21(18):6993-7000
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory