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Targeted Allele Detail
Symbol: Sagtm1Jnc
Name: S-antigen, retina and pineal gland (arrestin); targeted mutation 1, Jeannie Chen
MGI ID: MGI:2388373
Synonyms: arr1-, Arrb1tm1Jnc, arrestin-
Gene: Sag  Location: Chr1:87731402-87772880 bp, + strand  Genetic Position: Chr1, 44.44 cM
Germline Transmission:  Earliest citation of germline transmission: J:43294
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of the 5' promoter and exons 1 and 2 were replaced with a neomycin resistance cassette via homologous recombination. Gene expression was undetectable in rod cells of homozygous mutant animals as shown by Western blot analysis. (J:43294)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 9 strains available      Cell Lines: 0 lines available
Carrying any Sag Mutation:  31 strains or lines available
Original:  J:43294 Xu J, et al., Prolonged photoresponses in transgenic mouse rods lacking arrestin. Nature. 1997 Oct 2;389(6650):505-9
All:  42 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory