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Hoxb4tm2.1Nrm
Targeted Allele Detail
Nomenclature
Symbol: Hoxb4tm2.1Nrm
Name: homeobox B4; targeted mutation 2.1, Nancy R Manley
MGI ID: MGI:2388369
Synonyms: Hoxb4loxP
Gene: Hoxb4  Location: Chr11:96318267-96321638 bp, + strand  Genetic Position: Chr11, 59.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:71389
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThis allele is derived from Hoxb4tm2Nrm. Embryos from heterozygous Hoxb4tm2Nrm intercrosses were injected with a cre expression plasmid to remove the floxed neo cassette in the first coding exon. The deletion leaves behind a 78 bp insertion containing a loxP site in the first exon. The 78 bp insertion contains a stop codon in-frame with the Hoxb4 transcript. (J:71389)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hoxb4 Mutation:  13 strains or lines available
Notes
ES cell line = R1-45, a subline of R1..
References
Original:  J:71389 Manley NR, et al., Hoxb2 and hoxb4 act together to specify ventral body wall formation. Dev Biol. 2001 Sep 1;237(1):130-44
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory