Hoxa11^{tm2(Hoxa13)Ssp}
Targeted Allele Detail

Summary

• Symbol: Hoxa11^{tm2(Hoxa13)Ssp}
• Name: homeobox A11; targeted mutation 2, S Steven Potter
• MGI ID: MGI:2388356
• Gene: Hoxa11 Location: Chr6:52219086-52222784 bp, - strand Genetic Position: Chr6, 25.4 cM
• Alliance: Hoxa11^{tm2(Hoxa13)Ssp} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71402
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The exon 2 homeodomain of Hoxa11 as precisely replaced with the homeodomain of Hoxa13, and a floxed neo cassette was inserted into a region 3' of the gene for positive selection. Interestingly, the 3' neo insert results in disruption of the gene. (J:71402)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxa11 Mutation: 11 strains or lines available

Notes

ES cell line = R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl⁺) or E14.1 (129P2/OlaHsd).

References

• Original: J:71402 Zhao Y, et al., Functional specificity of the Hoxa13 homeobox. Development. 2001 Aug;128(16):3197-207
• All: 1 reference(s)