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Targeted Allele Detail
Symbol: Slc9a3tm1Ges
Name: solute carrier family 9 (sodium/hydrogen exchanger), member 3; targeted mutation 1, Gary E Shull
MGI ID: MGI:2388341
Synonyms: Nhe3-, NHE-3 -, Slc9a3-
Gene: Slc9a3  Location: Chr13:74121457-74169442 bp, + strand  Genetic Position: Chr13, 40.15 cM
Germline Transmission:  Earliest citation of germline transmission: J:70885
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by insertion of a neomycin resistance cassette into exon 6. Northern blot analysis of kidney and intestinal RNA detected a truncated mutant transcript lacking codons 320-821. The residues endcoded by the deleted sequences are required for Na+/H+ exhange. (J:70885)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc9a3 Mutation:  4 strains or lines available
Original:  J:70885 Schultheis PJ, et al., Renal and intestinal absorptive defects in mice lacking the NHE3 Na+/H+ exchanger. Nat Genet. 1998 Jul;19(3):282-5
All:  51 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory