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Hmox2tm1Poss
Targeted Allele Detail
Nomenclature
Symbol: Hmox2tm1Poss
Name: heme oxygenase 2; targeted mutation 1, Kenneth D Poss
MGI ID: MGI:2388325
Synonyms: HO-2-, HO2-, HO-2delta
Gene: Hmox2  Location: Chr16:4726361-4766742 bp, + strand  Genetic Position: Chr16, 2.46 cM, cytoband B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:29523
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsApproximately 80% of the coding region was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region included the putative membrane spanning region. Transcript was undetected in homozygous mutant mice by Northern blot analysis of brain tissue. An assay based on bilirubin production indicated complete functional ablation in homozygous mutant mice. (J:29523)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Hmox2 Mutation:  17 strains or lines available
References
Original:  J:29523 Poss KD, et al., Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. Neuron. 1995 Oct;15(4):867-73
All:  38 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory