Dab1^tm3Cpr
Targeted Allele Detail

Summary

• Symbol: Dab1^tm3Cpr
• Name: disabled 1; targeted mutation 3, Jonathan A Cooper
• MGI ID: MGI:2388311
• Gene: Dab1 Location: Chr4:103476556-104602041 bp, + strand Genetic Position: Chr4, 47.79 cM
• Alliance: Dab1^tm3Cpr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:74239
• Parent Cell Line: AK7 (ES Cell)
• Strain of Origin: 129S4/SvJaeSor

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Modified isoform(s))
• Mutation: Insertion
• Mutation details: A construct containing a loxP site flanked neomycin resistance gene cassette and a splice acceptor attached to a cDNA fragment followed by a polyadenylation signal was inserted in the endogenous locus. The cDNA is for the second coding exon onwards of the p45 isoform that lacks the C terminus of the longer isoform. (J:74239)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dab1 Mutation: 78 strains or lines available

References

• Original: J:74239 Herrick TM, et al., A hypomorphic allele of dab1 reveals regional differences in reelin-Dab1 signaling during brain development. Development. 2002 Feb 1;129(3):787-96
• All: 1 reference(s)