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Pde6brd10
Spontaneous Allele Detail
Nomenclature
Symbol: Pde6brd10
Name: phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide; retinal degeneration 10
MGI ID: MGI:2388259
Synonyms: Pde6brd1-J, rd10
Gene: Pde6b  Location: Chr5:108388391-108432397 bp, + strand  Genetic Position: Chr5, 53.07 cM
Mutation
origin
Strain of Origin:  CXB1/ByJ
Mutation
description
Allele Type:    Spontaneous
Mutation:    Nucleotide substitutions
 
Mutation detailsAn initial complementation test with Pde6b rd1 demonstrated allelism. Sequence analysis shows that the rd10 mutation is caused by a missense mutation in exon 13, which encodes the beta subunit of the protein. (J:75095)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pde6b Mutation:  146 strains or lines available
References
Original:  J:75095 Chang B, et al., Retinal degeneration mutants in the mouse. Vision Res. 2002 Feb;42(4):517-25
All:  66 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/15/2018
MGI 6.12
The Jackson Laboratory