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Targeted Allele Detail
Symbol: Cacna1btm1Hssh
Name: calcium channel, voltage-dependent, N type, alpha 1B subunit; targeted mutation 1, Hee-Sup Shin
MGI ID: MGI:2388140
Synonyms: Cav2.2-
Gene: Cacna1b  Location: Chr2:24603887-24763152 bp, - strand  Genetic Position: Chr2, 16.58 cM, cytoband A2
Germline Transmission:  Earliest citation of germline transmission: J:71480
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsSequence encoding a portion of the IS3 region was replaced with a cassette containing GFP and neo. Protein was undetected by Western blot analysis of brain tissue obtained from homozygous mutant mice. (J:71480)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cacna1b Mutation:  5 strains or lines available
Original:  J:71480 Kim C, et al., Altered Nociceptive Response in Mice Deficient in the alpha(1B) Subunit of the Voltage-Dependent Calcium Channel. Mol Cell Neurosci. 2001 Aug;18(2):235-45
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory