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Targeted Allele Detail
Symbol: Ikzf3tm1Kge
Name: IKAROS family zinc finger 3; targeted mutation 1, Katia Georgopoulos
MGI ID: MGI:2388132
Synonyms: Aio-, Aiodelta7-, Aiolos-
Gene: Ikzf3  Location: Chr11:98464902-98546031 bp, - strand  Genetic Position: Chr11, 61.75 cM
Germline Transmission:  Earliest citation of germline transmission: J:50626
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 0.35 kb region of exon 7 including the 5' splice acceptor site was replaced with a PGK-neo cassette via homologous recombination. Gene expression was absent in homozygous mutant animals as demonstrated by Northern blot analysis of spleen, bone marrow, and thymus samples using probes to exons 1-6 and exon 7. Immunohistochemical analysis of spleen sections from 4 week old homozygous mutant mice did not detect protein product. (J:50626)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ikzf3 Mutation:  1 strain or line available
Original:  J:50626 Wang JH, et al., Aiolos regulates B cell activation and maturation to effector state. Immunity. 1998 Oct;9(4):543-53
All:  12 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory