Ikzf3tm1Kge
Targeted Allele Detail
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Symbol: |
Ikzf3tm1Kge |
Name: |
IKAROS family zinc finger 3; targeted mutation 1, Katia Georgopoulos |
MGI ID: |
MGI:2388132 |
Synonyms: |
Aio-, Aiodelta7-, Aiolos- |
Gene: |
Ikzf3 Location: Chr11:98355728-98436857 bp, - strand Genetic Position: Chr11, 61.75 cM
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Alliance: |
Ikzf3tm1Kge page
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Germline Transmission: |
Earliest citation of germline transmission:
J:50626
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Parent Cell Line: |
J1 (ES Cell)
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Strain of Origin: |
129S4/SvJae
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: A 0.35 kb region of exon 7 including the 5' splice acceptor site was replaced with a PGK-neo cassette via homologous recombination. Gene expression was absent in homozygous mutant animals as demonstrated by Northern blot analysis of spleen, bone marrow, and thymus samples using probes to exons 1-6 and exon 7. Immunohistochemical analysis of spleen sections from 4 week old homozygous mutant mice did not detect protein product.
(J:50626)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Ikzf3 Mutation: |
30 strains or lines available
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Original: |
J:50626 Wang JH, et al., Aiolos regulates B cell activation and maturation to effector state. Immunity. 1998 Oct;9(4):543-53 |
All: |
12 reference(s) |
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