About   Help   FAQ
Tulp3tm1Jng
Targeted Allele Detail
Nomenclature
Symbol: Tulp3tm1Jng
Name: tubby-like protein 3; targeted mutation 1, Jurgen Naggert
MGI ID: MGI:2388066
Synonyms: Tulp3-
Gene: Tulp3  Location: Chr6:128298124-128332814 bp, - strand  Genetic Position: Chr6, 62.96 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70060
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA portion of exon 5 and exons 6-9 were removed and replaced with an in-frame GFP-neo construct via homologous recombination. The targeted mutation results in deletion of the C-terminus and part of the N-terminal region of the protein, and creates a fusion protein with GFP. Homozygous mutant embryos were identified by PCR genotype analysis. (J:70060)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 10 assay results
In Structures Affected by this Mutation: 15 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tulp3 Mutation:  44 strains or lines available
References
Original:  J:70060 Ikeda A, et al., Neural tube defects and neuroepithelial cell death in Tulp3 knockout mice. Hum Mol Genet. 2001 Jun 1;10(12):1325-34
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/23/2021
MGI 6.17
The Jackson Laboratory