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Targeted Allele Detail
Symbol: Htttm1.1Tna
Name: huntingtin; targeted mutation 1.1, Toshiharu Nagatsu
MGI ID: MGI:2388035
Gene: Htt  Location: Chr5:34761740-34912534 bp, + strand  Genetic Position: Chr5, 17.92 cM
Germline Transmission:  Earliest citation of germline transmission: J:76017
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted
Mutation:    Insertion
Mutation detailsThe endogenous exon 1 was replaced with human HD exon 1 sequence containing 77 CAG repeats. The floxed neo cassette was removed from Hdhtm1Tna by in vivo cre mediated excision in the germline. Western blot analysis of mutant mice showed the protein with the expanded polyglutamine tract to be expressed in a variety of tissues. (J:76017)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Htt Mutation:  25 strains or lines available
Original:  J:76017 Ishiguro H, et al., Age-dependent and tissue-specific CAG repeat instability occurs in mouse knock-in for a mutant Huntington's disease gene. J Neurosci Res. 2001 Aug 15;65(4):289-97
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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The Jackson Laboratory