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Targeted Allele Detail
Symbol: Numbtm1.1Zili
Name: NUMB endocytic adaptor protein; targeted mutation 1.1, Olav Zilian
MGI ID: MGI:2388023
Synonyms: Numb-
Gene: Numb  Location: Chr12:83794034-83921934 bp, - strand  Genetic Position: Chr12, 38.89 cM, cytoband D3
Germline Transmission:  Earliest citation of germline transmission: J:68652
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExon 1 was deleted by crossing animals carrying mutant allele Numbtm1Lso to the cre deleter line TgN(EIIa-cre)C5379Lmgd. Homozygous mutant embryos were observed up to day E10.5. RT-PCR analysis detected a mutant transcript lacking exon 1, and Western blot analysis detected a 65 kDa protein product presumably translated from methionine 55 of the mutant transcript. The truncated protein would not be functional since it lacks the arginine at position 53 required for binding activity. (J:68652)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Numb Mutation:  46 strains or lines available
Original:  J:68652 Zilian O, et al., Multiple roles of mouse Numb in tuning developmental cell fates. Curr Biol. 2001 Apr 3;11(7):494-501
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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