About   Help   FAQ
Numbtm1.1Zili
Targeted Allele Detail
Nomenclature
Symbol: Numbtm1.1Zili
Name: numb homolog (Drosophila); targeted mutation 1.1, Olav Zilian
MGI ID: MGI:2388023
Synonyms: Numb-
Gene: Numb  Location: Chr12:83794034-83921934 bp, - strand  Genetic Position: Chr12, 38.89 cM, cytoband D3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68652
Parent Cell Line:  GS1 (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 1 was deleted by crossing animals carrying mutant allele Numbtm1Lso to the cre deleter line TgN(EIIa-cre)C5379Lmgd. Homozygous mutant embryos were observed up to day E10.5. RT-PCR analysis detected a mutant transcript lacking exon 1, and Western blot analysis detected a 65 kDa protein product presumably translated from methionine 55 of the mutant transcript. The truncated protein would not be functional since it lacks the arginine at position 53 required for binding activity. (J:68652)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Numb Mutation:  44 strains or lines available
References
Original:  J:68652 Zilian O, et al., Multiple roles of mouse Numb in tuning developmental cell fates. Curr Biol. 2001 Apr 3;11(7):494-501
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory