Ltb^tm1Avt
Targeted Allele Detail

Summary

• Symbol: Ltb^tm1Avt
• Name: lymphotoxin B; targeted mutation 1, Alexei V Tumanov
• MGI ID: MGI:2388016
• Synonyms: ltb^flox
• Gene: Ltb Location: Chr17:35413483-35415281 bp, + strand Genetic Position: Chr17, 18.59 cM
• Alliance: Ltb^tm1Avt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:79129
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The endogenous allele was left flanked by loxP sites after a floxed neomycin selection cassette was excised via the transient expression of cre recombinase in vitro. (J:79129)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ltb Mutation: 18 strains or lines available

References

• Original: J:79129 Tumanov A, et al., Distinct role of surface lymphotoxin expressed by B cells in the organization of secondary lymphoid tissues. Immunity. 2002 Sep;17(3):239-50
• All: 16 reference(s)