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Mxd1tm1Rne
Targeted Allele Detail
Nomenclature
Symbol: Mxd1tm1Rne
Name: MAX dimerization protein 1; targeted mutation 1, Robert N Eisenman
MGI ID: MGI:2387993
Synonyms: Mad1tm1
Gene: Mxd1  Location: Chr6:86647042-86669161 bp, - strand  Genetic Position: Chr6, 37.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45945
Parent Cell Line:  AK7 (ES Cell)
Strain of Origin:  129S4/SvJaeSor
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encompassing the 5' untranslated region and exon 1 were replaced by a PGK-neo cassette inserted by homologous recombination. Transcript was undetected by RT-PCR analysis of a variety of tissues obtained from homozygous mutant mice. (J:45945)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mxd1 Mutation:  8 strains or lines available
References
Original:  J:45945 Foley KP, et al., Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation. EMBO J. 1998 Feb 2;17(3):774-85
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory