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Dnmt1tm1Jrc
Targeted Allele Detail
Nomenclature
Symbol: Dnmt1tm1Jrc
Name: DNA methyltransferase (cytosine-5) 1; targeted mutation 1, J Richard Chaillet
MGI ID: MGI:2387992
Synonyms: Dnmt1delta1o
Gene: Dnmt1  Location: Chr9:20907206-20959888 bp, - strand  Genetic Position: Chr9, 7.66 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:68455
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe oocyte-specific exon 1o and the proximal promoter region were deleted and replaced with a floxed HSV-tk-PGK-neo cassette. The resistance cassette was removed by transient expression of cre recombinase in correctly targeted ES cells. Immunohistochemical analysis of ovary sections from homozygous mutant animals confirmed the absence of gene expression in mutant oocytes. (J:68455)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 26 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dnmt1 Mutation:  45 strains or lines available
References
Original:  J:68455 Howell CY, et al., Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene. Cell. 2001 Mar 23;104(6):829-38
All:  4 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/13/2015
MGI 5.21
The Jackson Laboratory