Ksr1^tm1Shaw
Targeted Allele Detail

Summary

• Symbol: Ksr1^tm1Shaw
• Name: kinase suppressor of ras 1; targeted mutation 1, Andrey S Shaw
• MGI ID: MGI:2387975
• Synonyms: KSR^-
• Gene: Ksr1 Location: Chr11:78904266-79037233 bp, - strand Genetic Position: Chr11, 46.74 cM, cytoband B5
• Alliance: Ksr1^tm1Shaw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75739
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The exon encoding the CA2 domain was replaced by a neomycin selection cassette inserted by homologous recombination. While RT-PCR demonstrated that the neo cassette could be excised, Western blot analysis using both amino and carboxy terminal antibodies showed an absence of both normal truncated protein. (J:75739)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ksr1 Mutation: 50 strains or lines available

References

• Original: J:75739 Nguyen A, et al., Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol Cell Biol. 2002 May;22(9):3035-45
• All: 15 reference(s)