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Targeted Allele Detail
Symbol: Ksr1tm1Shaw
Name: kinase suppressor of ras 1; targeted mutation 1, Andrey S Shaw
MGI ID: MGI:2387975
Synonyms: KSR-
Gene: Ksr1  Location: Chr11:79013440-79146407 bp, - strand  Genetic Position: Chr11, 46.74 cM, cytoband B5
Germline Transmission:  Earliest citation of germline transmission: J:75739
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe exon encoding the CA2 domain was replaced by a neomycin selection cassette inserted by homologous recombination. While RT-PCR demonstrated that the neo cassette could be excised, Western blot analysis using both amino and carboxy terminal antibodies showed an absence of both normal truncated protein. (J:75739)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ksr1 Mutation:  13 strains or lines available
Original:  J:75739 Nguyen A, et al., Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol Cell Biol. 2002 May;22(9):3035-45
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory