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Targeted Allele Detail
Symbol: Fxyd4tm1Grt
Name: FXYD domain-containing ion transport regulator 4; targeted mutation 1, Haim Garty
MGI ID: MGI:2387972
Synonyms: CHIF -, CHIF KO
Gene: Fxyd4  Location: Chr6:117933559-117937692 bp, - strand  Genetic Position: Chr6, 55.7 cM
Germline Transmission:  Earliest citation of germline transmission: J:78904
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 3 through 5, encoding amino acids 1 through 33, were replaced with a neomycin selection cassette inserted by homologous recombination. The absence of transcript and protein in homozygous mutant mice was verified by Northern and Western blot analyses. (J:78904)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fxyd4 Mutation:  3 strains or lines available
Original:  J:78904 Aizman R, et al., Generation and phenotypic analysis of CHIF knockout mice. Am J Physiol Renal Physiol. 2002 Sep;283(3):F569-77
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory