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Targeted Allele Detail
Symbol: Ptger1tm1Jdm
Name: prostaglandin E receptor 1 (subtype EP1); targeted mutation 1, John D McNeish
MGI ID: MGI:2387971
Synonyms: EP1-
Gene: Ptger1  Location: Chr8:83666678-83672753 bp, + strand  Genetic Position: Chr8, 40.22 cM
Germline Transmission:  Earliest citation of germline transmission: J:79387
Parent Cell Line:  DBA-252 (ES Cell)
Strain of Origin:  DBA/1LacJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation details671 bp of coding sequence were replaced by the insertion of a neomycin selection cassette into exon 2. Transcript was undetected in liver, uterus, and kidney tissue by RT-PCR analysis and in situ hybridization of kidney tissue. Western blot analysis of Prkcl1 protein expression indicated that the targeting vector did not significantly disrupt the the Prkcl1 locus, which putatively overlaps the Ptger1 locus. (J:79387)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptger1 Mutation:  14 strains or lines available
Original:  J:79387 Stock JL, et al., The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure. J Clin Invest. 2001 Feb;107(3):325-31
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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