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Kcnc2tm1Rudy
Targeted Allele Detail
Nomenclature
Symbol: Kcnc2tm1Rudy
Name: potassium voltage gated channel, Shaw-related subfamily, member 2; targeted mutation 1, Bernardo Rudy
MGI ID: MGI:2387957
Synonyms: Kv3.2 -
Gene: Kcnc2  Location: Chr10:112271121-112467024 bp, + strand  Genetic Position: Chr10, 60.3 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:66730
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 3' portion of exon 1, encoding the tetramerization domain (T domain) involved in oligomerization of potassium voltage gated channel subunits, was replaced by a neomycin selection cassette inserted by homologous recombination. Neither transcript nor protein was detected by Northern and Western blot analyses of homozygous mutant mice. (J:66730)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kcnc2 Mutation:  12 strains or lines available
References
Original:  J:66730 Lau D, et al., Impaired fast-spiking, suppressed cortical inhibition, and increased susceptibility to seizures in mice lacking kv3.2 K+ channel proteins. J Neurosci. 2000 Dec 15;20(24):9071-85
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/08/2017
MGI 6.10
The Jackson Laboratory