Pou3f1^tm2Mejr
Targeted Allele Detail

Summary

• Symbol: Pou3f1^tm2Mejr
• Name: POU domain, class 3, transcription factor 1; targeted mutation 2, Dies Meijer
• MGI ID: MGI:2387951
• Synonyms: Oct-6^Puro
• Gene: Pou3f1 Location: Chr4:124551439-124554448 bp, + strand Genetic Position: Chr4, 57.86 cM
• Alliance: Pou3f1^tm2Mejr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:78939
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Modified regulatory region, Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A Schwann cell specific knockout was generated by replacing a 4.3 kb Schwann cell specific enhancer element downstream of the coding region with a floxed puromycin selection cassette. Mice carrying this allele were used to generate Pou3f1^tm2.1Mejr. (J:78939)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pou3f1 Mutation: 14 strains or lines available

References

• Original: J:78939 Ghazvini M, et al., A cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regeneration. EMBO J. 2002 Sep 2;21(17):4612-20
• All: 1 reference(s)