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Targeted Allele Detail
Symbol: Pou3f1tm2Mejr
Name: POU domain, class 3, transcription factor 1; targeted mutation 2, Dies Meijer
MGI ID: MGI:2387951
Synonyms: Oct-6Puro
Gene: Pou3f1  Location: Chr4:124656807-124660655 bp, + strand  Genetic Position: Chr4, 57.86 cM
Germline Transmission:  Earliest citation of germline transmission: J:78939
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA Schwann cell specific knockout was generated by replacing a 4.3 kb Schwann cell specific enhancer element downstream of the coding region with a floxed puromycin selection cassette. Mice carrying this allele were used to generate Pou3f1tm2.1Mejr. (J:78939)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou3f1 Mutation:  3 strains or lines available
Original:  J:78939 Ghazvini M, et al., A cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regeneration. EMBO J. 2002 Sep 2;21(17):4612-20
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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