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Irf4tm1Mak
Targeted Allele Detail
Nomenclature
Symbol: Irf4tm1Mak
Name: interferon regulatory factor 4; targeted mutation 1, Tak Mak
MGI ID: MGI:2387941
Synonyms: IRF-4-, IRF4-
Gene: Irf4  Location: Chr13:30749226-30766927 bp, + strand  Genetic Position: Chr13, 13.28 cM, cytoband A3.3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:42683
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 2 and 3 were replaced by a neomycin selection cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of concanavalin A activated lymph nodes obtained from homozygous mutant mice. (J:42683)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irf4 Mutation:  10 strains or lines available
References
Original:  J:42683 Mittrucker HW, et al., Requirement for the transcription factor LSIRF/IRF4 for mature B and T lymphocyte function. Science. 1997 Jan 24;275(5299):540-3
All:  55 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory