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Targeted Allele Detail
Symbol: Drd2tm1Ebo
Name: dopamine receptor D2; targeted mutation 1, Emiliana Borrelli
MGI ID: MGI:2387895
Synonyms: D2R-
Gene: Drd2  Location: Chr9:49340662-49407214 bp, + strand  Genetic Position: Chr9, 26.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:29045
Parent Cell Line:  P1 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2, which contains the translational start codon, was replaced by a neomycin selection cassette inserted by homologous recombination. Transcript was undetected in homozygous mutant mice by Northern blot analysis of RNA isolated from striata. An absence of functional protein was determined by radiolabeled ligand binding analyses. (J:29045)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Drd2 Mutation:  45 strains or lines available

Phenotypic Similarity to Human Syndrome: Cushing's syndrome

Phenotypic Similarity to Human Syndrome: Parkinson Disease (J:29045)

Original:  J:29045 Baik JH, et al., Parkinsonian-like locomotor impairment in mice lacking dopamine D2 receptors. Nature. 1995 Oct 5;377(6548):424-8
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.06
The Jackson Laboratory