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Targeted Allele Detail
Symbol: Rad50tm2Jpt
Name: RAD50 double strand break repair protein; targeted mutation 2, John H J Petrini
MGI ID: MGI:2387857
Synonyms: Rad50K22M, Rad50S
Gene: Rad50  Location: Chr11:53649519-53707319 bp, - strand  Genetic Position: Chr11, 31.98 cM, cytoband A5-B1
Germline Transmission:  Earliest citation of germline transmission: J:78820
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Inserted expressed sequence)
Mutation:    Nucleotide substitutions
Mutation detailsA lysine to methionine substitution at amino acid 22 (K22M) was introduced to exon 1 via homologous recombination and a floxed puromyin resistance cassette was inserted into the upstream intron. The puromycin cassette was excised by crossing mutant animals to the cre-expressing line Tg(CMV-cre)1Nagy. (J:78820)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rad50 Mutation:  24 strains or lines available
Original:  J:78820 Bender CF, et al., Cancer predisposition and hematopoietic failure in Rad50(S/S) mice. Genes Dev. 2002 Sep 1;16(17):2237-51
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.04
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