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Targeted Allele Detail
Symbol: Tbx5tm1.1Jse
Name: T-box 5; targeted mutation 1.1, Jonathan G Seidman
MGI ID: MGI:2387851
Synonyms: Tbx5-, Tbx5del, Tbx5delta
Gene: Tbx5  Location: Chr5:119832668-119885219 bp, + strand  Genetic Position: Chr5, 60.42 cM
Germline Transmission:  Earliest citation of germline transmission: J:71845
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsThis allele is derived from Tbx5tm1Jse. The floxed exon 3 and neo cassette were removed by crossing mutant animals to the cre-expressing transgenic line TgN(EIIa-cre)C5379Lmgd. This results in deletion of the N-terminal region of the T-box encoded by exon 3. RT-PCR analysis of mutant animals detected a truncated transcript lacking exon 3. (J:71845)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 67 assay results
In Structures Affected by this Mutation: 20 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx5 Mutation:  17 strains or lines available
Original:  J:71845 Bruneau BG, et al., A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell. 2001 Sep 21;106(6):709-21
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory