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Vav1tm2Bbd
Targeted Allele Detail
Nomenclature
Symbol: Vav1tm2Bbd
Name: vav 1 oncogene; targeted mutation 2, Mariano Barbacid
MGI ID: MGI:2387840
Synonyms: vav-
Gene: Vav1  Location: Chr17:57279100-57328031 bp, + strand  Genetic Position: Chr17, 29.76 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47596
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequences encoding amino acids 135-195 comprising the entire acidic domain were replaced with a PGK-neo cassette via homologous recombination. Gene expression was absent in thymocytes of homozygous mutant animals. (J:47596)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vav1 Mutation:  27 strains or lines available
References
Original:  J:47596 Fischer KD, et al., Vav is a regulator of cytoskeletal reorganization mediated by the T-cell receptor. Curr Biol. 1998 May 7;8(10):554-62
All:  15 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory