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Targeted Allele Detail
Symbol: Tnfrsf17tm1Kplm
Name: tumor necrosis factor receptor superfamily, member 17; targeted mutation 1, Kong-Peng Lam
MGI ID: MGI:2387797
Synonyms: BCMA-
Gene: Tnfrsf17  Location: Chr16:11313812-11320074 bp, + strand  Genetic Position: Chr16, 6.42 cM, cytoband B3
Germline Transmission:  Earliest citation of germline transmission: J:69599
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted by replacement of exon 3 with a neomycin resistance cassette via homologous recombination. The mutation deletes amino acids 119-143 which includes most of the intracellular domain, a region involved in binding TNF receptor-associated factors. (J:69599)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tnfrsf17 Mutation:  18 strains or lines available
Original:  J:69599 Xu S, et al., B-cell maturation protein, which binds the tumor necrosis factor family members BAFF and APRIL, is dispensable for humoral immune responses. Mol Cell Biol. 2001 Jun;21(12):4067-74
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory